2024年3月24日发(作者：)

专利内容由知识产权出版社提供

专利名称：NOVEL METHODS AND COMPOSITIONS

FOR DELIVERING MACROMOLECULES TO OR

VIA THE RESPIRATORY TRACT

发明人：BOT, Adrian,DELLAMARY, Luis, A.,SMITH, Dan

申请号：US2002013145

申请日：20020426

公开号：WO02/087542P1

公开日：20021107

摘要：Methods and compositions for delivering macromolecules to or via the

respiratory tract, such that the macromolecules exhibit improved local and/or systemic

bioavailability are provided. Such methods utilize lipid-based microstructures formed in

combination with at least one bioactive macromolecule, which have a superior ability to

rapidly release the bioactive macromolecule(s) thereby resulting in improved local

and/or systemic bioavailability of the bioactive macromolecule(s). Such improved

bioavailability is believed to be due, in part, to reduction of scavenging by

bronchoalveolar macrophages and/or mucociliary clearance. Compositions with improved

bioavailability are provided comprising a plurality of lipid-based microstructures formed

in combination with at least one bioactive macromolecule, wherein the bioavailability of

the bioactive macromolecule is improved by modifying the rate of release of the

bioactive macromolecule from the microstructure thereby reducing scavenging by

bronchoalveolar macrophages and/or mucociliary clearance.

申请人：INHALE THERAPEUTIC SYSTEMS, INC.

地址：US

国籍：US

代理机构：TUCKER, Guy, V.

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